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However, GLP-1 receptor knockout mice do not become obese [88], and deletion of the mouse Gcg gene (encoding GLP-1) from the entire intestine, resulting in a 90% reduction of circulating GLP-1, does not perturb food intake or weight gain [89]

Some GLP-1 receptor agonists, like Tirzepatide, have been shown to reduce the risk of major cardiovascular events (e.g., heart attack, stroke) in people with Type 2 diabetes and existing heart disease

Therapeutic category dynamics influence physician behavior

Many guidelines use about 14 g of fiber per 1,000 calories as a reference point

[DOI] [PMC free article] [PubMed] [Google Scholar] 73.Pradhan R., Yu O.H., Platt R.W., Azoulay L