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Key outcomes from the 84-week study: Mean weight loss: CagriSema 23% Tirzepatide 25.5% Treatment-regimen estimand (all randomized patients): CagriSema 20.2% Tirzepatide 23.6% While CagriSema demonstrated clinically meaningful weight reduction, it fell short of the predefined statistical threshold for non-inferiority
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Data extraction focused on diagnostic accuracy, treatment efficacy, safety profiles, and quality-of-life outcomes across 122 included studies
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