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doi: 10.1113/JP286680

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However, given the novelty of this therapeutic approach, the available evidence may be influenced by publication bias and early optimism, and long-term mechanistic and clinical outcome data remain limited

At 26 weeks after treatment, the weight loss was -2.29 0.24 kg for 1.5 mg DUL, -1.36 0.24 kg for 0.75 mg DUL, and -2.22 0.24 kg for metformin (110)

They influence appetite, satiety, gastric emptying, glucose regulation, insulin secretion, glucagon suppression, and other downstream metabolic pathways

They also called for randomised trials with standardised erectile dysfunction assessments to further explore the association and investigate underlying biological pathways