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HCD, high-cholesterol diet

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The Ca 2+ channel blockers -agatoxin and isradipine, respectively blocking voltage-gated Ca 2+ channels sensitive to -agatoxin (P/Q-type Ca 2+ channels) and L-type Ca 2+ channels, were from Alomone Labs (Jerusalem, Israel)

It reflects what the pharmacokinetic data shows about receptor adaptation and tolerability windows

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This finding aligns with research showing that metabolic flexibility decreases with age, potentially limiting responsiveness to hormone-based interventions