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However, musculoskeletal symptoms including arthralgia are listed in some product SmPCs with varying frequencies

It is not among the most common side effects, but some patients report a taste of metal in mouth and nausea, especially during the early stages of treatment

It found higher rates of wound dehiscence, delayed healing, surgical site infections, and hypertrophic (raised) scarring in the GLP-1 group

Given the paucity of evidence, there is concern whether patients on GLP-1RA are at higher risk of retained gastric contents and subsequent adverse outcomes during routine esophagogastroduodenoscopy (EGD)

Other notable adverse effects include: Injection site reactions such as erythema, pruritus, or swelling Fatigue reported in approximately 5% to 6% of patients Hypoglycemia when used in combination with insulin or sulfonylureas Increased heart rate with modest elevations of 2 to 4 beats per minute (a class effect of incretin therapies with uncertain clinical significance) Serious but rare adverse effects include acute pancreatitis, gallbladder disease (cholelithiasis, cholecystitis), acute kidney injury (typically secondary to dehydration from gastrointestinal symptoms), and hypersensitivity reactions

Last but not least in this group is pemvidutide, which is being developed not only for the treatment of obesity but also for the treatment of T2DM and nonalcoholic fatty liver disease