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Using perforated-patch whole-cell recordings of mouse -cells, intense trains of depolarizations were repeated to induce Ca 2+ influx leading to exocytosis

Results Identification of cyclohepta[ b ]indoles with GLP-1 releasing actions Using a three-component (4 + 3) annulation methodology developed by one of our groups (see Supplemental Material) 2 , we generated a library of cyclohepta[ b ]indoles (Fig