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Further, it was explained that the appetite-reducing effects promoted by GLP-1R stimulation effectively reduce caloric intake by inducing satiety and delaying gastric emptying, making it a prime target to counter hyperglycemia and overeating [107]

GIP has, in contrast to GLP-1, no effect on glucagon secretion, but also regulates fat metabolism in adipocytes (67)

Both NPY and PYY play a role in beta-cell survival and in glucose homeostasis (74)

The interest in GLP-1 receptor agonists for weight management stems from their diverse mechanisms of action

and Novo Nordisk and has received support for attending meetings and/or travel from Eli Lilly & Co