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Differences in molecular structure, efficacy, dosing frequency, and side effects exist between these drugs, making some options more suitable for certain patients

GLP-1s blueprint was finally decoded: it was not an independent molecule, but a fragment snipped from a larger protein called proglucagon

Evidence from clinical trials and the clinic suggests GLP-1-associated side effects are not uncommon

Its not about how often you inject, but about how much is being administered as your body adapts

Survodutide (from Boehringer Ingelheim) is another dual agonist targeting GLP-1 and glucagon, but without the GIP component

Continuing on to discontinuation rates we see another very interesting nugget that I have bolded below: Discontinuation rates due to adverse events were 12.2% and 18.2% with retatrutide 9 mg and 12 mg, respectively, compared to 4.0% with placebo