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Additionally, the appetite suppression that makes these medications effective for weight management may inadvertently reduce overall fluid intake, as patients often consume less food and beverages throughout the day

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Increasing evidence suggests that miRNAs regulate many genes and participate in many molecular pathways

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The UK SmPC notes that tirzepatide is not recommended in patients with severe gastrointestinal disease, including severe gastroparesis

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Tirzepatide (Mounjaro/Zepbound) I reach for this when more weight loss is needed, blood sugar is harder to control, or semaglutide wasn't tolerated

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The result is a compounding effect where genuine dehydration layers on top of medication-induced changes in salivary function

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Pathophysiology of the metabolic syndrome

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