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Additionally, the appetite suppression that makes these medications effective for weight management may inadvertently reduce overall fluid intake, as patients often consume less food and beverages throughout the day

Increasing evidence suggests that miRNAs regulate many genes and participate in many molecular pathways

The UK SmPC notes that tirzepatide is not recommended in patients with severe gastrointestinal disease, including severe gastroparesis
Tirzepatide (Mounjaro/Zepbound) I reach for this when more weight loss is needed, blood sugar is harder to control, or semaglutide wasn't tolerated
The result is a compounding effect where genuine dehydration layers on top of medication-induced changes in salivary function
Pathophysiology of the metabolic syndrome
