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Therefore, at a high level, its easy to see why metabolic function and electrolyte balance could be altered by starting GLP-1 RA therapy.In other words: These medications deliver higher hormone levels than your body produces naturally

Although it is possible that CRH may alter AGRP cellular activity independent of ionotropic induced changes in cellular activity, GLP1 effects on paraventricular hypothalamic nucleus CRH neurons may rely more heavily on modifying activity at target nuclei outside of the arcuate nucleus (Liu et al., 2017)