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This pattern is consistent with other GLP-1 receptor agonists, though the magnitude of the initial increase with retatrutide is slightly larger

These data are consistent with the idea that glutamine and asparagine trigger action potentials by electrogenic amino acid uptake coupled to Na + influx

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Specifically, the 4mg dose is being tested as a step-down option after initial weight loss on higher doses

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The advent of effective pharmacotherapies, such as GLP-1RAs, has disrupted these narratives, reframing obesity treatment within a medical context