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Irisin is another myokine produced in response to exercise, and regulates energy metabolism
Kim M, Platt MJ, Shibasaki T, Quaggin SE, Backx PH, Seino S, et al
Through a phase 2b trial, cotadutide 300 g was shown to significantly improve liver injury enzymes, propeptide of type III collagen level, FIB-4, and NAFLD fibrosis score compared to placebo (but not compared to liraglutide) and reduce body weight more than treatment with liraglutide 1.8 mg
Nature 379, 6972
Ball AK, Sinclair AJ, Curnow SJ, Tomlinson JW, Burdon MA, Walker EA, Stewart PM, Nightingale PG, Clarke CE, Rauz S
