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, Pyke, C

What the Trials Have Actually Shown So Far A phase 2 trial published in the New England Journal of Medicine found that 48 weeks of treatment with retatrutide, an agonist of the GIP, GLP-1, and glucagon receptors, produced substantial reductions in body weight among participants with obesity

Semaglutide mimics GLP-1, a natural hormone in your intestines that plays a critical role in controlling blood sugar levels after you eat

Minor outpatient procedures (dental work, endoscopy) may allow resumption within 2 to 3 days, while major abdominal or orthopedic surgery typically requires the full week to ten days

Research shows that GLP-1 agonists reduce food cravings and increase feelings of fullness at lower calorie intakes, potentially allowing athletes to maintain training intensity while in a deficit

However, the authenticity of this claim is still under examination