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Each generation of weight loss peptide activates more receptors, starts at a dose calibrated for that receptor load, and achieves greater weight loss at the therapeutic range

Nature 528, 262266

Ethics declarations Conflicts of Interest All authors are employees and shareholders of Novo Nordisk A/S

5153 Notably, of the different HF phenotypes, HFpEF is associated with the worst HRQoL, whereas among HFpEF patients, the worst HRQoL had been shown in a subgroup with the highest BMI, a higher proportion of at least Grade 2 obesity and T2D

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However, for many individuals, the choice isnt either-or