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One meta-analysis involving patients with T2D without cardiovascular disease found a reduction in MACE associated with SGLT2i regimens of (adjusted pooled OR and 95% CI) 0.82 (0.730.92), with GLP1-RAs regimens of 0.93 (0.811.06), and with combined therapy of 0.70 (0.500.98)

Still, they are not a cure-all

J Clin Endocrinol Metab 2022;107: e1339e1347

Curcumin induced secretion of GLP-1 in a dose-dependent manner

The FDA medications are extremely expensive

[DOI] [PMC free article] [PubMed] [Google Scholar] 63.Catalisano G., Campione G.M., Spurio G., Galvano A.N., di Villalba C.P., Giarratano A., Alongi A., Ippolito M., Cortegiani A