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Metformin was associated with reduced stroke ( P = .032) and reduced all-cause mortality ( P = .021)

10.1074/jbc.M205055200

, e13764

Most participants in the study, about 84%, had severe obesity (BMI above 3540), a group that often struggles the most with losing weight through traditional methods

You may also want to meet with a registered dietician for diet and meal planning advice

Finally, individuals with a history of heart failure, ischaemic heart disease, unstable angina, myocardial infarction, aortic aneurysm or dissection, stroke (ischaemic or haemorrhagic stroke), cerebral infarction, transient ischaemic attack, carotid intervention or surgery, coronary stenting, percutaneous coronary intervention (PCI) or coronary artery bypass before inclusion to the cohort or prior to the index event were also excluded