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Adjustments to surgical timing and method, as well as implementation of additional preventive measures, are warranted for high-risk patients

BMJ , e075354

The company also defended the safety of its active pharmaceutical ingredients, stating: "The APIs used to compound our Semaglutide and Tirzepitide (S&T) are sourced from reputable, internationally approved pharmaceutical manufacturers and have been tested in independent analytical laboratories for sterility and quality." In a striking claim, iDexis insisted it had dispensed its compounded product to over 200,000 patients without incident, writing: "To date we have dispensed our S&T compounded peptide product to 214 406 patients on prescription of their treating clinicians through the practices of their clinicians, or retail pharmacies of choice, without any reports of adverse reactions or conditions, only reports of great success and gratitude being expressed." iDexis went further, accusing SAHPRA of attempting to improperly influence the outcome of an ongoing court case: "We are of the opinion that the impugned findings of SAHPRA are nothing other than unsophisticated attempts orchestrated to improperly influence the outcome of the court case, especially in the light of the official investigation by SAHPRA launched in 2025 into the desirability of compounding peptides, in respect of which SAHPRA has not published any findings to date." The matter is scheduled to be heard in the Gauteng High Court in Pretoria on June 10 and 11, 2026
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