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A funnel plot is suggestive of the presence of most of the studies outside the plot, hence it is likely that significant publication bias is present DISCUSSION Obesity has severe health consequences, with each 5 kg/m 2 increase in BMI beyond the normal range linked to a 30% increase in mortality and a potential reduction in life expectancy by up to 10 years.[16] Conversely, significant weight loss is associated with metabolic and non-metabolic benefits

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Results here will determine whether retatrutide can pursue a combined obesity-and-diabetes indication on its label, which matters commercially: diabetes coverage by Medicare and most commercial insurers is substantially broader than obesity-only coverage

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