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Ile 27 - From positions 3335 of GLP-1, each replacement with Ala increases the IC 50 about five-fold but somewhat decreases the EC 50

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42,43 Several GLP-1R agonists, including exenatide, liraglutide, and semaglutide, have been used in NASH clinical research

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In the periphery, posttranslational processing of preproglucagon in the alpha-cells of the pancreas produces glucagon and a small amount of GLP-1 whereas the main source of peripheral GLP-1 production occurs through the posttranslational processing of preproglucagon in the L-cells of the gut (reviewed in Holst, 2007 and Campbell and Drucker, 1992