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Glucagon-like peptide-1 receptor agonists in the treatment of idiopathic inflammatory myopathy: from mechanisms of action to clinical applications

Quick Stats for GLP-1 Diabetes Treatment Drugs Market GLP-1 Diabetes Treatment Drugs Market Value (2025): USD 6,556.5 million GLP-1 Diabetes Treatment Drugs Market Forecast Value (2035): USD 62,543.2 million GLP-1 Diabetes Treatment Drugs Market Forecast CAGR: 25.3% Leading Drug Type in GLP-1 Diabetes Treatment Drugs Market: Liraglutide (35.5%) Key Growth Regions in GLP-1 Diabetes Treatment Drugs Market: Asia Pacific, North America, and Europe Top Key Players in GLP-1 Diabetes Treatment Drugs Market: Eli Lilly, Sanofi, Novo Nordisk, Hanmi Pharmaceutical Co., Boehringer Ingelheim, AstraZeneca, Pfizer Inc., Teva Pharmaceutical Industries Ltd, GlaxoSmithKline (GSK), Ganli Pharmaceuticals, Tonghua Dongbao, Shanghai Renhui Biopharmaceuticals Co., Ltd., Huadong Medicine, Page Biopharmaceuticals, Jiangsu Hausen Pharmaceuticals Group Co., Ltd

The findings highlight the spinal microglial GLP-1R/-endorphin pathway involved in the modulating of pain hypersensitivity induced by bone cancer [24]

The dual GIP/GLP-1 mechanism may provide additional anti-inflammatory and bone-protective effects through GIP receptor activation

In addition, our data unambiguously documented that the effects of this and other multi-functional analogs on body weight and food intake are not merely due to food aversion or malaise linked to gastrointestinal distress, regarded as one of the main side-effects of GLP1-based therapy in humans 49