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Moreover, the use of antidepressants has been contestable in BD because of the risk of manic switch or rapid cycling

On the latter, studies conducted using site-specific brain micro-injections and single-photon emission computed tomography documented a novel regulatory role of the hypothalamic supramammillary nucleus in the regulation of food intake and reward, posing this brain area as one of the main targets of the GLP1/E conjugate, along with the lateral hypothalamus and the nucleus of the solitary tract, whose activation may be responsible for the anorectic, weight-lowering and reward reducing effects of this multi-agonist 51

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Structure Therapeutics: GSBR-1290 [60] [61] [60] [61] An oral GLP1R agonist, currently being studied in a double-blinded, placebo-controlled Phase 2a clinical trial

The SUSTAIN 7 head-to-head trial comparing Ozempic with dulaglutide (another GLP-1 RA) found that Ozempic 0.5 mg reduced HbA1c by 1.5% (16 mmol/mol) and the 1 mg dose by 1.8% (20 mmol/mol) from baseline