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The increase was modest and did not produce clinical events in the trial population, but researchers with pre-existing cardiovascular conditions should factor this into their risk assessment

This occurs because appetite returns to pre-treatment levels and the body's metabolic adaptations to weight loss persist, making weight maintenance challenging without continued intervention

Vomiting, diarrhea, constipation, and reflux symptoms are also reported

The practical fix: protein-first meals at scheduled times, 1.2-1.6 g per kg body weight daily, with a calorie floor of about 1200-1400 for women and 1500-1800 for men

Labs are not required to start or continue treatment, but Fridays coordinates optional blood work through Quest Diagnostics for patients who want or need it