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Wadden, A

May have higher risk of GI or metabolic side effects

doi: 10.1210/en.2013-1934 56 RawshaniA.RawshaniA.GudbjornsdottirS

A supplement that also includes protein or gut-friendly ingredients like prebiotics or digestive enzymes may help offset muscle loss and bloating
Ongoing research is exploring these issues and looking at combining GLP-1 agonists and dual agonists with other treatments for more comprehensive weight management[2][4]

and (3) experimental studies