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Reconstituted solution at room temperature for less than 24 hours is generally usable

That is why higher concentrations exist

once-weekly semaglutide 2.4 mg in adults with overweight or obesity (~15% mean weight loss)

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This potential use would be informal initially, as there is very little or no formal clinical guidance on the use of pharmacotherapy to maintain weight loss, but as clinical trials have shown that people who discontinue AOMs typically regain weight, it is highly likely that real world use of these agents will include use to maintain weight loss and therefore that lower cost semaglutide may be preferred

The timing of dose escalations should be individualized based on patient-specific factors including tolerance to the medications side effects, as determined by the prescribing provider