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However, some individuals report heightened appetite sensitivity in the weeks following severe illness, which may require temporary dose adjustment or closer monitoring of hunger cues

doi: 10.3389/fendo.2022.1044030 [DOI] [PMC free article] [PubMed] [Google Scholar] 46

GLP-1 directly stimulates POMC/CART neurons and indirectly inhibits neuropeptide Y (NPY) and agouti-related peptide (AgRP) to increase measures of satiety and decrease hunger [32]

Nausea represents the most frequently reported gastrointestinal side effect, occurring in approximately 17-30% of patients depending on dose and indication, with higher rates typically seen at higher doses and in the weight management indication

10.1016/s0168-8227(88)80022-6 122 WculekS

"I don't know how to present myself right now," she said at the time