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Semaglutide can restore the decreased gut microbiota diversity in db/db mice and reverse the changes in specific bacterial levels induced by a high-fat diet (HFD) (Mao et al., 2024

Always use a new, sterile needle for each injection and never share devices with another person

[DOI] [PubMed] [Google Scholar] 95.Efrat S., Teitelman G., Anwar M., Ruggiero D., Hanahan D

Patients with optimized variants may feel effects within 34 days, while others require 23 weeks

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Weeks 1-4: 1mg weekly (4mg total, small portion of first vial) Weeks 5-8: 2mg weekly (8mg total) Weeks 9-12: 4mg weekly (16mg total, finish first vial and start second) Weeks 13-16: 6mg weekly (24mg total, continue through second vial) Weeks 17-20: 8mg weekly (32mg total) Weeks 21-24: 8mg weekly maintenance (32mg total) Total peptide required: 116mg over 24 weeks Vials needed: 6 x 20mg vials with some remaining This protocol reaches 8mg maintenance by week 17 and holds there through week 24