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The 68week STEP 4 trial used a withdrawal design: after a 20week runin period with openlabel semaglutide, participants were randomized to continued semaglutide 2.4 mg versus switch to placebo (both as adjunct to lifestyle intervention) (Figure S1)

Both work by blocking estrogen receptors, but raloxifene is more selective, targeting breast tissue without stimulating other estrogen-sensitive areas

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In case of infections the swollen lymph nodes usually disappears in a couple of days without treatment

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This helps reduce friction during use and supports compliance through transparent education and daily guidance