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These findings provide a mechanistic basis for the direct cardiovascular actions of GLP-1RAs, revealing their potential to modulate key disease drivers like fibrosis and lipotoxicity

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In adults with type 2 diabetes inadequately controlled on metformin, Orforglipron dropped A1C by up to 1.7%, compared to 0.8% with Farxiga

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Posttranslationally modified amino acids are crucial in physiology and drug development as they alter physicochemical properties such as the solubility of proteins