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Given that the glucose-lowering effect of metformin is so strong and is independent of incretin signalling, it might be difficult to detect the beneficial effect of metformin on the incretin axis in human studies
Gaykema, R

Because of these broad effects, we wanted to see whether they would reduce all-cause mortality compared with another more weight-neutral diabetes medication. Mavromatis and colleagues conducted an observational study in which they used the Optum database to identify 170,030 adults (mean age, 56.8 years

Declaration of interest C R A and A A declare no conflicts of interest

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