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doi: 10.1016/j.ejpb.2008.10.008 69 ColucciPDAngeloPMautoneGScarsiCDucharmeMP

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8,801 received a placebo

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Finally, restrain-free production run was carried out for each simulation, with a time step of 2 fs in the NPT ensemble at 310 K and 1 bar using the Nose-Hoover thermostat and the semi-isotropic Parrinello-Rahman barostat 68 , respectively

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Published Phase 2 trial data (for example, Jastreboff et al., NEJM 2023) have explored doses ranging from approximately 1 mg up to 12 mg administered once weekly

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