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However, the dosing and pharmacokinetics are designed so that both receptors receive clinically meaningful activation

Diarrhea Diarrhea is less common than constipation but still affects 5%25% of patients, most often in the first few weeks of therapy

PMCID: PMC10911117

And if the goal is purely performance and theres no medical indication, consider that the same time and effort invested in dialing in training, nutrition, and recovery is likely a far safer path to improvement than relying on a pharmaceutical shortcut

He advises clinicians to assess patients mental health before starting treatment

Pharmaceutical companies spend years running tightly regulated clinical trials to determine the safest and most effective doses