why would semaglutide not work for me How Long Does Suppress Appetite How Fast Does Semaglutide Work?

The patients who do best on GLP-1s are not the ones following strict rules or perfect meal plans

Yet a common challenge emerges: after 3 to 6 months of steady losses, the scale stops moving, even though you're following the same regimen

Hardonova M, Siarnik P, Sivakova M, Sucha B, Penesova A, Radikova Z et al

But this effect, if it exists, appears to be minimal and might be offset by the higher trough levels providing more consistent appetite control in the back half of each three-to-four day cycle

10.1016/j.obpill.2024.100127 [DOI] [PMC free article] [PubMed] [Google Scholar] 3.Nauck MA, Meier JJ (2016) The incretin effect in healthy individuals and those with type 2 diabetes: physiology, pathophysiology, and response to therapeutic interventions

This included, for instance, negative feedback from 5-HT 2C receptor agonism onto ghrelin levels in overnight fasted mice (Nonogaki et al., 2006)