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doi: 10.3390/ph16050736 40

Tirzepatide has demonstrated sustained weight loss through 72 weeks with minimal regain, establishing its durability

Nevertheless, metformin also impacts the microbiome in the small intestine, causing distinct changes in the microbiota of the duodenum, jejunum, and ileum in rodents (Sun et al., 2018)

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It also became evident that utilizing such combination therapy might result in a more effective strategy toward curtailing cardiometabolic risks rather than relying on individual treatments alone