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The drug also appeared to be effective across different subgroups of patients, including men with low-volume and high-volume cancer

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It has been associated with complications from diabetic retinopathy

Many of these studies have focused on exploring absorption, metabolism, or pharmacokinetics of the drug in plasma or urine although recent work studying the distribution of the drug in rodent brains has been attempted [40]

The absence of a published interaction trial is an evidence gap, not a safety certificate

[DOI] [PMC free article] [PubMed] [Google Scholar] 78.Rubi B., Ljubicic S., Pournourmohammadi S., Carobbio S., Armanet M., Bartley C., Maechler P