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Considering GLP-1s or Phentermine for weight loss

Originally developed and positioned as treatments for type 2 diabetes, these agents are now equally associated with weight management, reshaping how clinicians, patients, and pharmacies understand metabolic disease

Retatrutide is a triple receptor agonist activating GLP-1R, GIPR, and GCG-R pathways to reduce appetite, improve insulin secretion, and support metabolic health

A 2026 case report describes a 34-year-old man with obesity and alcohol use disorder whose semaglutide treatment for weight loss was associated with a marked drop in drinking over 10 months, with his AUDIT score falling from 27 to 7 and alcohol use dropping from about 15 drinks per week to half a beer per month

Semaglutide was approved in 2017 as Ozempic for diabetes, and in 2021 as Wegovy for obesity

Here, we aimed to provide an overview of retatrutide's safety and effectiveness in treating obesity.