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Chiquette E, Toth PP, Ramirez G, Cobble M, Chilton R: Treatment with exenatide once weekly or twice daily for 30 weeks is associated with changes in several cardiovascular risk markers

Consider switching to a different GLP-1

When to speak to your GP Contact your GP if you experience: New or worsening muscle pain, tenderness, or weakness (could indicate a statin-related issue that needs investigating) Persistent nausea or vomiting that prevents you from taking your statin consistently Dark-coloured urine alongside muscle pain (rare but warrants urgent assessment) Significant weight loss, as your statin dose or other cardiovascular medications may need reviewing Dizziness or lightheadedness, particularly if you also take blood pressure medication Feelings of anxiety or low mood related to managing multiple medications Dont stop taking your statin without speaking to your GP first, even if youre losing weight and your cholesterol levels are improving

In the STEP-3 trial (N=611), only 7% of semaglutide participants discontinued treatment due to gastrointestinal adverse events of any kind [7]

However, the companys written policies also allowed employees to dismiss reports coming directly from patients who were not asked for their consent to follow up

Concerns have been expressed regarding the effects of these drugs on pancreatic and thyroid tissue, since animal studies and analyses of drug databases indicate an association of GLP-1 receptor agonists with pancreatitis, pancreatic cancer, and thyroid cancer
