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Upper respiratory tract infections (URTIs) were the most frequently reported adverse event (8 of 12 reporting studies, 66.7%), occurring at rates comparable to controls across RCTs (GRADE: MODERATE certainty)

Diabetes mellitus (DM) and obesity are closely inter-related and pose a major burden on health care in terms of morbidity and mortality

If proven effective in clinical trials, this approach could improve convenience, treatment adherence, and possibly even tolerability for many patients