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This review article aims to clarify the therapeutic role of the oral formulation of the glucagon-like peptide 1 receptor agonist (GLP-1 RA) semaglutide in treating typical T2D patients

Caution is advised in patients with a history of pancreatitis or severe gastrointestinal disease, including severe gastroparesis, as Rybelsus may exacerbate these conditions

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Taking a double dose typically causes severe gastrointestinal symptoms including nausea, vomiting, and diarrhea that may lead to dehydration

Gastrointestinal Symptoms Nausea, bloating, and gastrointestinal discomfort are common side effects of GLP-1 medications, particularly early in treatment or after dose increases

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