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If Tirzepatide is working well for you and your doctor determines it is safe, you will likely take it for an extended period to manage your blood sugar and/or weight

Clinical trials show combination therapy produces an average weight loss of 8 to 12 pounds beyond what either drug achieves individually

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Alongside nausea, many patients report reduced appetite (the intended effect), constipation, and occasional vomiting, particularly if they eat large meals or high-fat foods