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Earlier this year, Veru reported that stair climb power declined by 10% for 42% of older adults with just 16 week on semaglutide in its Phase 2b study an androgen receptor agonist (enobosarm)

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doi: 10.1038/nature04410

Nevertheless, pharmacological levels of OXM (sufficient to activate GLP-1R and GCGR) have shown anti-obesity effects in humans, by significantly reducing appetite (108, 109) and increasing energy expenditure (110)

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That position reflects a practical clinical need because the 2025 joint advisory set protein intake at 1.2-1.6 g/kg/day for GLP-1 users, a level many patients will struggle to reach through reduced food intake alone