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The rodent Gcg promoter, along with its adjacent DNA control/enhancer elements, is located within the 2.5 kb 5-flanking region of the Gcg transcription start [89,93,94]

In septic mice, semaglutide attenuated sickness behavior, hypothermia, systemic inflammation, and lung injury through the downregulation of pro-inflammatory cytokines (TNF- , IL-1, IL-6, CXCL1), suppression of neutrophil infiltration, and decreased expression of genes associated with tissue remodeling and inflammation (Mmp9, Timp1, Ly6g)

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This might have hampered the incentive to investigate the potential effects of GLP1 receptor agonists as a treatment against AUD, as patients are already at a higher risk for developing pancreatitis or pancreatic cancer (National Institute for Health and Care Excellence, 2011)

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Looking for possible candidates, they were inspired by Lise Hedings work on glucagon and her identification of the immunological differences between gut and pancreatic glucagon (28)