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Rectal body temperature Conscious mice were restrained and a high-precision thermometer (BIO-TK8851, Bioseblab) was carefully inserted half-way into the rectum

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Larger molecules like dulaglutide and albiglutide, which are fusion proteins with albumin or Fc domains, have molecular weights approaching or exceeding 60,000 Da, rendering them virtually impermeable to the BBB through classical routes

Abstract BACKGROUND: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) offer cardiorenal benefits in diabetes management

Eleven of the nineteen studies included in this systematic review had a randomized, double-blind placebo-controlled study design [9,17,18,21,22,23,29,30,31,32,33], one study had a single-center open-label comparative study design [24], one study had a prospective design [26], one study had a prospective single-center parallel-group design [28], one study had a prospective randomized study design [27], one study had a prospective randomized placebo-controlled study design [25], one study had an interventional casecontrol study design [35], one study was a prospective analysis [36], and one study had a matched group design [34]