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This is why our approach focuses on personalized care and clinical oversight

Conclusion GLP-1 medications are undeniably powerful tools for weight loss but are not standalone solutions

Furthermore, we unexpectedly find that in vivo, the loss of GLP-1/Notch activity leads to a generalised dramatic increase in COL IV levels throughout the animal

Regular moderate exercise improves GLP-1 sensitivity and overall metabolic health

(12 kg)

Future studies are needed to investigate the durability of weight loss retention and metabolic benefits, especially based on the less encouraging results of regaining lost weight [93,99], and it is not yet clear whether the trajectory of weight regain continues in subsequent years