retatrutide ly3437943 phase 2 trial obesity nejm 2023 Another Promising Medication (Retatrutide) for 🧬 R3TA is a next-generation

nevertheless, their most pronounced effect in obesity is appetite reduction through central nervous system (CNS) mechanisms, mainly within the hypothalamus [35]

Williams, 2021)

Although data from early phase trials suggest that retatrutide is well tolerated with a similar adverse event profile to GLP-1 RAs, additional research assessing long-term safety and efficacy of retatrutide in people living with obesity and/or T2D (including cardiovascular outcomes) is awaited over the next five years

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