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People on thyroid medications If you take levothyroxine (Synthroid, Levoxyl) or other thyroid medications, timing becomes complicated

Wyne KL, Litwin SE, Cusi K, Guyton JR

Change history 25 March 2026 A Correction to this paper has been published: Abbreviations AOM: Anti-obesity medication WMD: Weighted mean difference CI: Confidence interval SD: Standard deviation RCT: Randomized controlled trial GLP-1 RA: Glucagon-like peptide 1 receptor agonist GIP: Glucose-dependent insulinotropic polypeptide GCCR: Glucagon receptor BMI: Body mass index References World Obesity Federation

It contains naltrexone (an opioid antagonist) and bupropion (an atypical antidepressant) that work on different neurochemical pathwaysprimarily the hypothalamus and reward centersrather than on GLP-1 receptors

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However, individual response varies