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Both SUSTAIN-6 and LEADER showed a statistically significant decrease in MACE [53, 54]

Although initially developed for Type 2 diabetes management, Rybelsus has been prescribed off-label to assist individuals without diabetes who are seeking weight loss

Clinical practices and adoption rates among providers Patient compliance and adherence Mixed sentiments abound in both the healthcare and insurance industries about actual take-up rates, with some bullish about the outlook given the hype generated both in the clinical setting and commercially

Acknowledgments Parts of the figures were generated using Servier Medical Art, provided by Servier ( licensed under CC BY 4.0 ( and NIH BIOART Source ( Author Contributions Conceptualization, M.J

GLP-1 has received attention as being the chief contributor to ileal brake mechanisms of the upper gastrointestinal tract regarding gastric and pancreatic secretion and gastric emptying (75, 76)