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Details of the search strategy are provided in the Supplementary Table S1

Conclusion The GLP-1 revolution is one of those rare moments in medicine when a class of drugs reshapes clinical expectations

Most patients notice reduced appetite within 37 days of their first injection

Moreover, it has recently been reported that metformin inhibits the apical sodium-dependent bile acid transporter and thus may increase the concentration of bile acids in the intestine [12], which could stimulate GLP-1 secretion from L cells via the G-protein-coupled receptor TGR5 [13]

In head-to-head trials, tirzepatide consistently outperformed semaglutide for weight loss

And the results medications are used without support, short-term wins followed by long-term costs