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There has also been impact on decreasing the chance of developing or recurrent cardiovascular disease such as heart attacks or stroke.

However, this is in direct contradiction with other reports that identified the paraventricular hypothalamic nucleus as required in the control of food intake via CNSderived GLP1 (Liu et al., 2017)

New mechanisms for weight loss are continually being explored, offering new potential drug targets from cannabinoid receptor blockers, nucleotide-binding domain, leucine-richcontaining family, pyrin domaincontaining-3 (NLRP3) inhibitors, free fatty acid receptor 2 (FFA2) inhibitors and gene-editing RNA therapy

Experts note that many patients discontinue the use of weight-loss medications due to side effects

Additionally, the pooled result showed that adding GLP-1 treatment was more effective compared with metformin alone or placebo for improving menstrual frequency

doi: 10.3748/wjg.v20.i22.6912 78 ValentiniLWirthEKSchweizerUHengstermannSSchaperLKoernickeTet al