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Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist, a class of medications designed to mimic the action of the naturally occurring hormone GLP-1

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A previous mediation analysis of semaglutide in adults with overweight or obesity suggested that less than one percentage point of the body weight reduction achieved with subcutaneous semaglutide was attributable to gastrointestinal adverse events (246)

Acute Pancreatitis: Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with GLP-1 RAs

It ranked second for likelihood to take the next step, overall appeal, personal relevance, and shifting perceptions of GLP-1 medications