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Key Points: GI symptoms are the most common adverse effects, ranging from expected nausea and vomiting to gastroparesis and, rarely, functional obstruction Delayed gastric emptying has important airway implications and a cautious approach to airway management is warranted Biliary disease is one of the most clinically significant complications, particularly early in treatment and with rapid weight loss Pancreatitis is rare, and current evidence does not support a strong causal relationship EDKA and AKI are uncommon but important to recognize in the right context Conclusions: GLP-1 receptor agonists have transformed the management of diabetes and obesity, with clear benefits in weight loss, glycemic control, and cardiovascular outcomes

Meta-analyses of randomized controlled trials (RCTs) reveal that GLP-1RAs decrease hepatic steatosis by approximately 45% and improve histological features of steatohepatitis (7, 19)

[7] Novo Nordisk

Common side effects include nausea, vomiting, and digestive issues, such as bloating or constipation